Symptoms of premature ovarian failure

To understand premature ovarian failure, it is necessary to first understand ovarian function. On the one hand, the ovary produces eggs and ovulates, which is an important organ for ensuring female reproductive offspring. On the other hand, it supports reproductive endocrine function and secretes hormones related to the female body.

The balance of hormone levels in women's bodies directly affects their health and beauty.

Premature ovarian failure refers to the phenomenon in which a woman has established regular menstruation after puberty, but before the age of 40, due to the decline of ovarian function, ovulation and secretion dysfunction, amenorrhea or oligomenorrhea, and atrophy of sexual organs occur. Clinical manifestations include various symptoms, so it is medically referred to as premature ovarian failure.

Once premature ovarian failure occurs, the most typical clinical manifestation is unquestionably cessation of menstruation before the age of 40. At the same time, an increase in gonadotropins (FSH, LH) and a decrease in estrogen (E2) were found in blood biochemical tests.

① Menstrual disorders：Before the age of 40, there may be symptoms such as infrequent menstruation, shortened menstrual periods, decreased menstrual flow, and gradually approaching amenorrhea. It is also possible that the previous stage of menstruation had a regular pattern of monthly menstruation and suddenly stopped.

② Infertility：Manifested as secondary infertility and infertility.

③ Perimenopausal syndrome：Manifested as paroxysmal heat, sweating, flushing, emotional fluctuations, irritability, irritability, and reduced work efficiency. Prolonged amenorrhea can also lead to symptoms such as genital atrophy, difficulty in sexual activity, and decreased libido. Over time, it can also cause changes in blood lipid metabolism, arteriosclerosis, and even lead to premature coronary heart disease.

④ Manifestations of osteoporosis：Such as unexplained joint pain, lower back pain, and susceptibility to fractures.

⑤ B-ultrasound examination：It was found that the uterus and ovaries are smaller than those of women of the same age, and the endometrium is thinner. No follicular development is observed in the ovaries, or although there are follicles, they are very small, few, or even absent.

⑥ Hormonal examination：The levels of follicle stimulating hormone and luteinizing hormone in the blood remain consistently high, especially when follicle stimulating hormone exceeds 40 international units per liter, while estrogen levels are low, with estradiol below 0.05 millimoles per liter.

⑦ Basal body temperature measurement：For single-phase body temperature, vaginal exfoliation cell test indicates low estrogen levels.

Based on the above symptoms, signs, and examination results, diagnosing premature ovarian failure is not difficult, but it is difficult to identify the causes of premature failure. Unfortunately, even if the cause is identified, premature aging is irreversible due to ovarian failure. Subsequent treatment mainly focuses on immediate needs. So, preventing premature aging is the fundamental.